TRAF6-dependent NF-kB transcriptional activity during mouse development

Glutamate-dependent activation of NF-kappaB during mouse cerebellum development.

NF-kappaB and activator protein 1 (AP-1) are dimeric transcription factors involved in transcriptional regulation in many cells, including neurons. We have examined their activity during mouse cerebellum development, a postnatal process starting just after birth and completed by the fourth postnatal (PN) week. The activity of these factors was analyzed by binding of nuclear extracts to a synthe...

Human Cytomegalovirus Upregulates NF-kB Activity by Transactivating the NF-kB p105/p50 and p65 Promoters

During human cytomegalovirus (HCMV) infection, a series of regulated events take place following virus binding and entry into the cell, including the upregulation of cellular transcription factors, such as NF-kB, which play an essential role in the viral life cycle. We show here that NF-kB message is induced during HCMV infection and that the induction is biphasic, suggesting an initial inducti...

[Ca]i Oscillation Frequency Regulates Agonist-stimulated NF-kB Transcriptional Activity*

In nonexcitable cells, stimulation by high agonist concentrations typically produces a biphasic increase in cytosolic Ca ([Ca]i). This response is characterized by a transient initial increase because of intracellular Ca release followed by a sustained elevation which varies in amplitude depending on the nature of the stimulus. In contrast, low-level stimulation often evokes oscillatory changes...

DBC1 Is a Suppressor of B Cell Activation by Negatively Regulating Alternative NF-kB Transcriptional Activity

T Cell - dependent Induction of NF - KB in B Cells

In comparison to B cell stimulation mediated by surface immunoglobulin (Ig) antigen receptor ligation, little is known about the intracellular events associated with T cell-dependent B cell responses. A model for the efferent phase of T cell-B cell interaction was used to examine the capacity of activated T cells to trigger nuclear expression of the trans-acting transcription factor, NF-KB, in ...